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Yong Tao (陶勇), Principal Investigator
课题组长Principal Investigator

陶勇Yong Tao

研究员 · 博士生导师
云南大学生命科学学院
Professor · Doctoral Supervisor
School of Life Sciences, Yunnan University

Cancer Genomics · Cancer Epigenetics · Epigenome Editing · Aging

  • Email:Email: taoyong@ynu.edu.cn · taoyong.ac@gmail.com
  • 地址:云南省昆明市呈贡区 云南大学生命科学学院Address: School of Life Sciences, Yunnan University, Chenggong District, Kunming, Yunnan

简介Biography

陶勇,云南大学生命科学学院研究员、博士生导师。2002 年本科毕业于华中农业大学植物科学专业,2009 年于中国科学院遗传与发育生物学研究所获理学博士学位(分子遗传学)。2009–2014 年任中国科学院北京基因组研究所助理研究员、副研究员;2014–2019 年在美国约翰霍普金斯大学(Johns Hopkins University)医学院从事博士后研究;2019–2022 年在美国弗雷德·哈钦森癌症中心(Fred Hutch Cancer Center)从事博士后研究。2022 年 6 月入职云南大学生命科学学院。 Yong Tao is a Professor and doctoral supervisor at the School of Life Sciences, Yunnan University. He received his B.S. in Plant Science from Huazhong Agricultural University in 2002 and his Ph.D. in Molecular Genetics from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, in 2009. He served as Assistant and then Associate Investigator at the Beijing Institute of Genomics, CAS (2009–2014), and conducted postdoctoral research at the Johns Hopkins University School of Medicine (2014–2019) and Fred Hutch Cancer Center (2019–2022). He joined Yunnan University in June 2022.

课题组以组织类器官、肿瘤细胞系、肿瘤类器官和小鼠模型为体系,综合运用遗传学、表观遗传学、基因组学与细胞生化方法,研究结肠干细胞的命运决定与结肠癌发生之间的关系,以及雄激素受体阳性前列腺癌在治疗过程中发生细胞命运转分化的分子机制,并致力于推动结肠癌与前列腺癌的临床管理。 The lab uses tissue organoids, cancer cell lines, tumor organoids, and mouse models, combining genetics, epigenetics, genomics, and cell biochemistry to study how colonic stem-cell fate decisions relate to colorectal tumorigenesis, and the molecular mechanisms of cell-fate transdifferentiation in androgen receptor-positive prostate cancer under therapy — with the goal of improving clinical management of both cancers.

相关工作以第一作者或共同作者发表于 NatureCancer CellPNASClinical Epigenetics 等期刊。 This work has appeared in Nature, Cancer Cell, PNAS, and Clinical Epigenetics, among others.

教育与工作经历Education & Appointments

  • 1998–2002 华中农业大学,植物科学,理学学士Huazhong Agricultural University — B.S., Plant Science
  • 2002–2009 中国科学院遗传与发育生物学研究所,分子遗传学,理学博士Institute of Genetics and Developmental Biology, CAS — Ph.D., Molecular Genetics
  • 2009–2014 中国科学院北京基因组研究所,助理研究员 → 副研究员Beijing Institute of Genomics, CAS — Assistant then Associate Investigator
  • 2014–2019 约翰霍普金斯大学医学院,博士后Johns Hopkins University School of Medicine — Postdoctoral Fellow
  • 2019–2022 弗雷德·哈钦森癌症中心,博士后Fred Hutch Cancer Center — Postdoctoral Fellow
  • 2022–至今present 云南大学生命科学学院,研究员、博士生导师School of Life Sciences, Yunnan University — Professor, Doctoral Supervisor

研究方向Research Interests

从表观遗传编辑工具的开发,到衰老驱动的肿瘤发生机制,再到临床转化。 From building epigenome-editing tools, to aging-driven tumorigenesis, to clinical translation.

01

表观基因编辑工具开发Epigenome Editing Tools

开发基于病毒样颗粒(VLP)的定点表观遗传编辑系统,用于在肿瘤细胞特异的表观改变中系统鉴定驱动性事件,并探索其治疗应用。 Developing virus-like-particle (VLP)-based targeted epigenome editing systems to systematically identify driver events among tumor-specific epigenetic alterations, and to explore their therapeutic use.

02

衰老、表观遗传与肿瘤发生Aging, Epigenetics & Tumorigenesis

自发的启动子区 DNA 甲基化沉默在衰老与早期肿瘤发生中共同出现。我们研究衰老相关甲基化如何影响细胞命运调控并驱动肿瘤发生,服务于肿瘤早诊与治疗。 Spontaneous promoter DNA methylation silencing arises in both aging and early tumorigenesis. We study how aging-associated methylation shapes cell-fate control and drives cancer, informing early detection and therapy.

03

结肠干细胞命运与左右半结肠差异Colonic Stem-Cell Fate & Left–Right Asymmetry

研究衰老相关甲基化改变阻断右半结肠干细胞分化的分子机制,以及左、右半结肠癌在分子特征、临床表现与预后上系统差异的成因。 Dissecting how aging-associated methylation blocks differentiation of right-sided colonic stem cells, and why left- and right-sided colorectal cancers differ systematically in molecular features, presentation, and outcome.

代表性论文Selected Publications

  • Epigenetic Editing Approaches Maturity: AI-Driven Precision Design, Delivery Innovation, and the Road to Clinical Translation. Clinical Epigenetics, 2026. (通讯作者)(Corresponding author)
  • Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications. Biology, 2025;14(7):805. (通讯作者)(Corresponding author)
  • Adjuvant Epigenetic Therapy Inhibits Lung Metastases by Disrupting the Pre-Metastatic Niche. Nature, 2020;579(7798):284–290.
  • Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis. Cancer Cell, 2019;35(2):315–328.e6. (共同第一作者)(Co-first author)
  • Rapid Growth of a Hepatocellular Carcinoma and the Driving Mutations Revealed by Cell-Population Genetic Analysis of Whole-Genome Data. PNAS, 2011;108(29):12042–12047.
  • A Transcriptomic Analysis of Super Hybrid Rice LYP9 and Its Parents. PNAS, 2009;106(19):7695–7701. (共同第一作者)(Co-first author)
  • Histone Acetyltransferases and Their Inhibitors in Tumor Immunotherapy. Springer Nature, 2026 (专著章节,唯一作者)(Book chapter, sole author).

查看完整论文列表 →See full publication list →

在研项目与专利Funding & Patents

主持项目Grants

在研课题Active Projects

  • 云南大学杰出人才协同创新团队:肝癌靶点发现与基因治疗临床转化研究团队(2025–2028)YNU Outstanding Talent Collaborative Innovation Team — liver cancer target discovery and gene-therapy translation (2025–2028)
  • 云南省科技厅–云南大学联合项目:基于病毒样颗粒递送系统的表观基因编辑技术在肝癌治疗中的应用开发(2023–2026)Yunnan Provincial S&T Department–YNU joint project — VLP-delivered epigenome editing for liver cancer therapy (2023–2026)
  • 云南大学医学科研基金:肠道衰老与结直肠癌发生中的表观遗传学机制研究(2024–2027)YNU Medical Research Fund — epigenetic mechanisms linking intestinal aging and colorectal cancer (2024–2027)
  • 云南大学医学科研基金重大项目:间充质干细胞外泌体雾化吸入治疗频发室性早搏的安全性与有效性研究(2025–2028)YNU Medical Research Fund (Major) — nebulized MSC-derived exosomes for frequent ventricular premature beats (2025–2028)
  • 国家自然科学基金:肿瘤组织内不同肿瘤细胞群体的遗传变异与演化规律(2013–2015)NSFC — genetic variation and evolutionary dynamics of tumor cell populations (2013–2015)
专利Patents

发明专利申请Patent Applications

  • 一种 β-Catenin 靶向沉默工具及其应用(第一发明人,2025 年申请,已请求实质审查)A β-catenin-targeted silencing tool and its applications — first inventor, filed 2025, under substantive examination
  • 一种病毒样颗粒的递送体系及其病毒样颗粒(云南大学 + 中国科学技术大学,2026 年 3 月进入实质审查)A virus-like-particle delivery system — Yunnan University & USTC, entered substantive examination in March 2026
  • Methods to amplify very low amounts of bisulfite-treated DNA…(Johns Hopkins 发明披露,2016)Methods to amplify very low amounts of bisulfite-treated DNA… — Johns Hopkins invention disclosure, 2016

教学与学术服务Teaching & Academic Service

本科生课程Undergraduate

授课Courses

  • 肿瘤生物学Cancer Biology
  • 衰老生物学Biology of Aging
  • 发育生物学Developmental Biology
研究生课程Graduate

授课Courses

  • 高级遗传学Advanced Genetics
  • 生命科学进展Frontiers in Life Sciences
  • 细胞生物学Cell Biology
学术兼职Service

学会与会议Societies & Meetings

  • 中国遗传学会代谢分会 委员Committee member, Metabolism Branch, Genetics Society of China
  • 2026 年 12 月于昆明承办中国遗传学会代谢分会学术年会Host of the Branch's 2026 annual meeting in Kunming (December 2026)

联系与加入Contact & Join

课题组常年招收博士生、硕士生与本科科研训练学生,也欢迎在表观遗传学、衰老生物学与肿瘤演化方向开展合作。 The lab continuously recruits Ph.D. students, M.S. students, and undergraduate researchers, and welcomes collaborations in epigenetics, aging biology, and tumor evolution.

Email: taoyong@ynu.edu.cn · taoyong.ac@gmail.com

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