从现象到机制，从机制到工具——理解衰老与肿瘤的表观遗传本质，并发展精准干预策略。 From phenomenon to mechanism, from mechanism to intervention — understanding the epigenetic basis of aging and cancer.
衰老是肿瘤最大的风险因素。我们研究组织衰老过程中细胞身份如何逐步腐蚀，以及这种腐蚀如何重塑微环境、积累致癌易感性，最终促进肿瘤发生。 Aging is the greatest risk factor for cancer. We study how cell identity progressively erodes during tissue aging, and how this erosion remodels the microenvironment, accumulates oncogenic susceptibility, and ultimately promotes tumorigenesis.
表观遗传调控异常是连接衰老与肿瘤的核心纽带。我们聚焦 DNA 甲基化等关键表观修饰在衰老和肿瘤中发生异常的分子机制，揭示细胞身份腐蚀的调控逻辑。 Epigenetic dysregulation is the central link between aging and cancer. We focus on the molecular mechanisms by which key epigenetic modifications such as DNA methylation become aberrant during aging and tumorigenesis, uncovering the regulatory logic of cell identity erosion.
理解机制的最终目标是实现干预。我们基于蛋白从头设计（de novo protein design）开发新一代表观基因组编辑工具，精准操控特定位点的表观遗传状态，为衰老延缓与肿瘤治疗提供新策略。 The ultimate goal of understanding mechanisms is to enable intervention. We leverage de novo protein design to develop next-generation epigenome editing tools for precise manipulation of locus-specific epigenetic states, opening new strategies for aging intervention and cancer therapy.